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Evidence is increasing that most addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This section of the problem regulates reward responses in acquiring food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the amount of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).
Using two separate drugs to lose weight can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it one should err assisting caution and let the FDA do its job and demand some investigation be done so your public understands the side effects and hazards of the medications before we take them. Keep in mind that drug companies come in business to earn money and that they would say everything to keep people on the medications.
Researchers found that participants investing in this drug to get a year, lost excess weight within four weeks and have kept the extra weight off through the entire 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them far better and safer.
Combo-pilling will be the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular could be the fact that since right now there are no long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be authorized by the FDA.
Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug could also raise hypertension and heartrate, and really should not be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy while using drug.
The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high hypertension, in addition to by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients with a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.
"This will be the first drug I'm conscious of that targets both the appetite and reward centres inside the brain," he explained.
